Polyphenol composition and biological activity of Thymus citriodorus and Thymus vulgaris: Comparison with endemic Iberian Thymus species
Data
2020
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Resumo
The polyphenol compositions of Thymus × citriodorus and Thymus vulgaris extracts as obtained by exhaustive
hydroethanolic (HE) extraction and aqueous decoction (AD) were compared. In addition, their compositions and
bioactivities were compared to those of Thymus pulegioides and Thymus mastichina, grown under the same
edaphoclimatic conditions, and Thymus carnosus. Rosmarinic acid was the most abundant polyphenol followed
by luteolin-hexuronide, salvianolic acids I and K. Cluster analysis suggests a similarity of the polyphenol composition of T. citriodorus and T. vulgaris. A significant antioxidant activity was observed and correlated with their
polyphenol levels. The same being observed for the higher anti-proliferative activity/cytotoxicity of HE extracts
on Caco-2 and HepG2 cells as compared to AD extracts. Significant association between the total phenolic
compounds with the anti-proliferative activity, for both cell lines, was observed. These results support the importance of salvianolic acids levels in Thymus extracts and their in vitro anti-proliferative/cytotoxic activities.
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Thymus L. species , Thymus × citriodorus