Please use this identifier to cite or link to this item: http://hdl.handle.net/10348/10921
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dc.contributor.authorTaghouti, Meriempt_PT
dc.contributor.authorMartins-Gomes, Carlospt_PT
dc.contributor.authorSchäfer, Judithpt_PT
dc.contributor.authorSantos, J. A.pt_PT
dc.contributor.authorBunzel, Mirkopt_PT
dc.contributor.authorNunes, Fernando M.pt_PT
dc.contributor.authorSilva, Amélia Mpt_PT
dc.date.accessioned2021-12-21T15:10:02Z-
dc.date.available2021-12-21T15:10:02Z-
dc.date.issued2019-
dc.identifier.issn2076-3921-
dc.identifier.urihttp://hdl.handle.net/10348/10921-
dc.description.abstractThymus mastichina, also called mastic thyme or Spanish marjoram, is endemic to the Iberian Peninsula, where it is widely used in folk medicine especially for treating digestive and respiratory systems disorders, and as a condiment to season olives. This work describes for the first time the detailed phenolic composition of exhaustive hydroethanolic extracts and aqueous decoctions of Thymus mastichina. Unlike other species of the Thymus genera, Thymus mastichina extracts contain high amounts of salvianolic acid derivatives, with salvianolic acid A isomer being the main derivative. This isomer was identified in extracts from Thymus mastichina for the first time. Also, an undescribed salvianolic acid derivative in Thymus mastichina was identified and its structure was tentatively described. Extracts from Thymus mastichina showed significant scavenging activity of 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radical cation, hydroxyl, and nitric oxide radicals. The anti-proliferative effect of both T. mastichina extracts were tested against Caco-2 and HepG2 cells; the hydroethanolic extract showed a high antiproliferative activity against Caco-2 cells compared to HepG2 cells (at 24 h exposure, the concentration that inhibits 50% of proliferation, IC50, was 71.18 ± 1.05 µg/mL and 264.60 ± 11.78 µg/mL for Caco-2 and HepG2, respectively). Thus, these results make this species a promising candidate for further investigation of its anti-tumoral potential. Therefore, Thymus mastichina can be potentially used as a functional food (used as a decoction or herbal tea) or as a source of bioactive ingredients with antioxidant and anti-proliferative properties.pt_PT
dc.language.isoengpt_PT
dc.relation.ispartofCITAB - Centro de Investigação e de Tecnologias Agro-Ambientais e Biológicaspt_PT
dc.rightsopenAccesspt_PT
dc.subjectThymus mastichinapt_PT
dc.subjectphenolic profilingpt_PT
dc.titleChemical Characterization and Bioactivity of Extracts from Thymus mastichina: A Thymus with a Distinct Salvianolic Acid Compositionpt_PT
dc.typearticlept_PT
degois.publication.titleAntioxidantspt_PT
degois.publication.volume9pt_PT
dc.peerreviewedyespt_PT
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