Avaliação dos níveis séricos de somatomedina C e amiloide A em gengivoestomatite crónica felina
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2020-03-06
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A gengivoestomatite crónica felina (GECF), tal como o próprio nome indica, é uma doença que afeta a cavidade oral dos gatos e é caracterizada por lesões do tipo ulcerativo ou ulcero-proliferativo, associadas a uma intensa inflamação oral. A amiloide A sérica (SAA) e a somatomedina C, esta última vulgarmente designada de “Insulin-like Growth Factor-1” (IGF-1), são consideradas proteínas de fase aguda. As mesmas podem ser utilizadas como indicadores de diagnóstico e monitorização em doenças sistémicas. Contudo, o seu comportamento perante um processo inflamatório é consideravelmente diferente, uma vez que a concentração sérica de SAA aumenta e a de IGF-1 diminui. O principal objetivo deste trabalho foi o de determinar os níveis séricos de SAA e IGF-1 numa amostra populacional de gatos diagnosticados com GECF e, posteriormente, compará-los com os intervalos de referência disponibilizados na literatura para esses mesmo parâmetros. De modo a cumprir esse objetivo, selecionaram-se oito gatos com GECF e sem outras comorbilidades diagnosticadas. Procedeu-se à mensuração da concentração sérica de SAA e IGF-1 nestes animais, recorrendo às técnicas laboratoriais de nefelometria e quimioluminescência, respetivamente. Foi possível constatar que a maior parte das concentrações de SAA obtidas do grupo de estudo (2,3536 ± 3,7319 mg/L) se encontraram dentro do intervalo de referência determinado (1,8 ± 2,3 μg/mL). Relativamente às concentrações séricas de IGF-1 dos gatos estudados (226,33 ± 91,47 μg/L), todas elas estiveram dentro do intervalo tido como referência para esse parâmetro (<795 ng/mL). Até ao momento e, sendo do conhecimento dos autores, nunca tinham sido reportados os valores séricos de SAA e IGF-1 em gatos com GECF. Os resultados obtidos neste estudo indiciam que ambos os biomarcadores inflamatórios não são os mais indicados no momento do diagnóstico de GECF, não permitindo determinar o estadio inflamatório sistémico associada a esta doença.
As the name implies, feline chronic gingivostomatitis is a disease that affects the oral cavity of cats and is characterized by ulcerative or ulcerative-proliferative lesions, associated with intense oral inflammation. Serum amyloid A (SAA) and somatomedine C, also refered to as “Insulin-like Growth Factor-1” (IGF- 1), are considered acute phase proteins. These can be used as indicators of diagnosis and monitoring of systemic diseases. However their behaviour through an inflamatory process is considerably diferent, as SAA concentration rises and IGF-1 decreases. The main goal of this Master´s dissertation was to determine the concentrations of SAA and IGF-1 in a population sample of cats diagnosed with feline chronic gingivostomatitis and compared it to the reference intervals available in the literature for each parameter. To achieve this goal eight cats with feline chronic gingivostomatitis but without any concomitante disease were selected. SAA and IGF-1 concentrations were measured using nephrometry and chemiluminescence laboratory techniques, respectively. It was found that most of SAA concentrations obtained in this study group (2,3536 ± 3,7319 mg/L) were within the determined reference range (1,8 ± 2,3 μg/ mL). Concerning the IGF-1 serum concentrations in studied cats (226,33 ± 91,47 μg/L), all of them were within the reference range (<795ng/mL). To this moment, and to the authors knowledge, the serum concentrations for SAA and IGF-1 in cats with chronic gingivostomatitis had never been reported. The results obtained in the study show that neither of the inflamatory biomarkers are the most indicated to diagnose feline chronic gingivostomatatis, not allowing to determine the systemic inflammatory stage associated with this disease.
As the name implies, feline chronic gingivostomatitis is a disease that affects the oral cavity of cats and is characterized by ulcerative or ulcerative-proliferative lesions, associated with intense oral inflammation. Serum amyloid A (SAA) and somatomedine C, also refered to as “Insulin-like Growth Factor-1” (IGF- 1), are considered acute phase proteins. These can be used as indicators of diagnosis and monitoring of systemic diseases. However their behaviour through an inflamatory process is considerably diferent, as SAA concentration rises and IGF-1 decreases. The main goal of this Master´s dissertation was to determine the concentrations of SAA and IGF-1 in a population sample of cats diagnosed with feline chronic gingivostomatitis and compared it to the reference intervals available in the literature for each parameter. To achieve this goal eight cats with feline chronic gingivostomatitis but without any concomitante disease were selected. SAA and IGF-1 concentrations were measured using nephrometry and chemiluminescence laboratory techniques, respectively. It was found that most of SAA concentrations obtained in this study group (2,3536 ± 3,7319 mg/L) were within the determined reference range (1,8 ± 2,3 μg/ mL). Concerning the IGF-1 serum concentrations in studied cats (226,33 ± 91,47 μg/L), all of them were within the reference range (<795ng/mL). To this moment, and to the authors knowledge, the serum concentrations for SAA and IGF-1 in cats with chronic gingivostomatitis had never been reported. The results obtained in the study show that neither of the inflamatory biomarkers are the most indicated to diagnose feline chronic gingivostomatatis, not allowing to determine the systemic inflammatory stage associated with this disease.
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Dissertação de Mestrado Integrado em Medicina Veterinária
Palavras-chave
gengivoestomatite crónica felina , gato