Decrease of E-cadherin expression in canine cutaneous histiocytoma appears to be related to its spontaneous regression.
| dc.contributor.author | Pires, Isabel | |
| dc.contributor.author | Queiroga, Felisbina | |
| dc.contributor.author | Alves, Anabela | |
| dc.contributor.author | Silva, Filipe | |
| dc.contributor.author | Lopes, Carlos | |
| dc.date.accessioned | 2013-09-24T09:45:28Z | |
| dc.date.available | 2013-09-24T09:45:28Z | |
| dc.date.issued | 2009 | |
| dc.description.abstract | Background: Canine cutaneous histiocytoma (CCH) is an epidermotropic tumour of Langerhans cells, most frequent in young dogs, which undergoes spontaneous regression. Materials and Methods: E-cadherin immunoexpression was analysed in ninety-three CCH, categorized according to Cockerell and Slauson (1976) criteria into four histological groups, representing different stages of tumour regression. Results: All tumours expressed membranous Ecadherin both in keratinocytes, and in tumoural cells and no differences were noted among the histological groups analysed.However, the intensity of the E-cadherin immunolabeling decreased in the presence of lymphoid infiltration and varied significantly among the groups considered (p<0.0001).Conclusion: This study strongly suggests a down-regulation of E-cadherin expression in CCH pathogenesis and progression.The loss of E-cadherin expression might represent an activation/ maturation process of the tumoural cells constituting a switch for CCH regression | por |
| dc.identifier.uri | http://hdl.handle.net/10348/2747 | |
| dc.language.iso | eng | por |
| dc.relation.ispartof | CECAV - Centro de Ciência Animal e Veterinária | por |
| dc.rights | open access | por |
| dc.subject | Canine cutaneous histiocytoma | por |
| dc.subject | E-cadherin | por |
| dc.subject | immunohistochemistry | por |
| dc.subject | tumour regression | por |
| dc.title | Decrease of E-cadherin expression in canine cutaneous histiocytoma appears to be related to its spontaneous regression. | por |
| dc.type | journal article | por |
| degois.publication.firstPage | 2713 | por |
| degois.publication.lastPage | 2718 | por |
| degois.publication.title | Anticancer Research | por |
| degois.publication.volume | 29 | por |
| dspace.entity.type | Publication | en |
Ficheiros
Principais
1 - 1 de 1