Epithelioid hemangiosarcomas of the bovine urinary bladder: a histologic, immunohistochemical, and ultrastructural examination of four tumors.

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dc.contributor.authorPires, Isabel
dc.contributor.authorSilva, Filipe
dc.contributor.authorQueiroga, Felisbina
dc.contributor.authorHenriques, Rui
dc.contributor.authorPinto, Carlos
dc.contributor.authorLopes, Carlos
dc.date.accessioned2013-09-24T09:43:23Z
dc.date.available2013-09-24T09:43:23Z
dc.date.issued2010
dc.description.abstractEpithelioid hemangiosarcoma is a specific variant of hemangiosarcoma that has recently been recognized in domestic animals. These malignant vascular neoplasms histologically resemble, and may be mistaken for, carcinomas. Four epithelioid hemangiosarcomas in the urinary bladders of 4 cows with severe enzootic hematuria are described in the current study. Grossly, the vesicular mucosa of the urinary bladder of each cow contained a single red elevated nodule. Histologically, each neoplasm was composed of short strands, cords, or nests of epithelioid, round, or slightly spindle-shaped endothelial cells that formed small vascular structures. Neoplastic cells were immunohistochemically positive for factor VIII-related antigen and vimentin, and were negative for cytokeratin and desmin. Ultrastructurally, the neoplastic cells often contained cytoplasmic intermediate filaments, a prominent granular endoplasmic reticulum, a Golgi complex, mitochondria, marked pinocytotic activity, and rare Weibel-Palade bodies. These neoplasms were diagnosed as epithelioid hemangiosarcomas based on their histologic, immunohistochemical, and ultrastructural features. The present report widens the spectrum of mesenchymal tumors of the bovine urinary bladder and aids in the characterization of these vascular neoplasms.por
dc.identifier.issn1040-6387
dc.identifier.urihttp://hdl.handle.net/10348/2745
dc.language.isoengpor
dc.publisherSage Publicationspor
dc.relation.ispartofCECAV - Centro de Ciência Animal e Veterináriapor
dc.relation.publisherversionhttp://vdi.sagepub.com/content/22/1/116por
dc.rightsopen accesspor
dc.subjectCattlepor
dc.subjectepithelioid hemangiosarcomapor
dc.subjectimmunohistochemistrypor
dc.subjectultrastructurepor
dc.subjecturinary bladderpor
dc.subjectvascular neoplasmpor
dc.titleEpithelioid hemangiosarcomas of the bovine urinary bladder: a histologic, immunohistochemical, and ultrastructural examination of four tumors.por
dc.typejournal articlepor
degois.publication.firstPage116por
degois.publication.lastPage119por
degois.publication.titleJournal of veterinary diagnostic investigationpor
degois.publication.volume22por
dspace.entity.typePublicationen
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