Efeito da radioterapia no tratamento de tumores intracranianos no cão: meningiomas e gliomas
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2016
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A radioterapia tem sido considerada a terapia de eleição para vários tumores cerebrais no cão, nomeadamente o glioma e o meningioma intracraniano.
Após ter sido realizada uma revisão acerca da técnica e dos dois tipos de tumor, em particular, procedeu-se à realização de um estudo de caráter retrospetivo, com dados relativos a doentes tratados no hospital VRCC - Veterinary Referrals, no Reino Unido.
Os objetivos definidos foram avaliar a eficácia desta abordagem terapêutica e procurar estabelecer associações entre várias características epidemiológicas, clínicas, diagnósticas e terapêuticas com o tipo tumoral e os tempos de sobrevivência apresentados. Assim, foram incluídos 32 cães com diagnóstico de glioma ou meningioma intracraniano, tratados com radioterapia, cujos relatórios clínicos foram analisados. Procedeu-se, ainda, ao cálculo de dois tempos de sobrevivência: o total (TST) e o pós-tratamento (TSPT), que se assumiram desde o diagnóstico ou do fim da radioterapia, respetivamente, até à morte ou final do período de estudo. Apenas 30 doentes foram considerados para os cálculos de sobrevida.
O sexo e o realce pós-contraste exibiram associações estatisticamente significativas (P<0.05) com o diagnóstico tumoral. Estes resultados traduziram-se numa predisposição sexual dos machos para o tipo glial e das fêmeas para o tipo meningeal e numa maior especificidade do realce pós-contraste, observado na ressonância magnética, para o meningioma. Verificou-se, ainda, que, apenas, a raça e o sexo se assumiram como fatores de prognóstico, tendo estado associados significativamente (P<0.05) com os tempos de sobrevivência. Ser da raça boxer ou labrador retriever, bem como ser fêmea constituem, assim, um benefício na sobrevida destes doentes. Os valores medianos obtidos foram de 372 dias para o TSPT e de 446.5 dias para o TST, em termos globais. As taxas de sobrevida ao final de 1 e 2 anos foram, respetivamente, de 50% e 23.3%.
A radioterapia é, assim, uma metodologia de tratamento eficaz nestes quadros neoplásicos, apresentando resultados superiores a outras abordagens terapêuticas.
Radiation therapy has been considered the treatment of choice for many brain tumors in dogs, like glioma and intracranial meningioma. After a review about the technique and these two types of tumor, in particular, a retrospective study was carried out, with the informations of patients treated in the hospital VRCC - Veterinary Referrals, in United Kingdom. The goals were set to evaluate the efficacy of this therapeutic approach and to search associations between different epidemiological, clinical, diagnostic and therapeutic features with the tumor type and the survival times. This study included 32 dogs diagnosed with glioma and intracranial meningioma which undergone radiation therapy. The clinical reports were analyzed. Two survival times were calculated: overall (OST) and post-treatment (PTST), from the diagnosis or the end of the radiation, respectively, until death or end of the study period. Only 30 patientes were considered for these survival calculations. Sex and contrast enhancement exhibited statistically significant associations (P<0.05) with tumor diagnosis. These results showed a sexual predisposition of males for glial type and females for meningeal type and a greater specificity of contrast enhancement, observed on MRI, for meningioma. It was found that just the breed and the sex are prognostic factors, as they were significantly associated (P<0.05) with survival times. Boxer and labrador retriever breeds and the female sex were considered as a survival benefit in these patients. Median values were 372 days for TSPT and 446.5 days for the TST. The 1- and 2-year survival rates were, respectively, 50% and 23.3%. Thus, radiation therapy is an effective treatment option for these neoplastic cases, with better results than other therapeutic approaches.
Radiation therapy has been considered the treatment of choice for many brain tumors in dogs, like glioma and intracranial meningioma. After a review about the technique and these two types of tumor, in particular, a retrospective study was carried out, with the informations of patients treated in the hospital VRCC - Veterinary Referrals, in United Kingdom. The goals were set to evaluate the efficacy of this therapeutic approach and to search associations between different epidemiological, clinical, diagnostic and therapeutic features with the tumor type and the survival times. This study included 32 dogs diagnosed with glioma and intracranial meningioma which undergone radiation therapy. The clinical reports were analyzed. Two survival times were calculated: overall (OST) and post-treatment (PTST), from the diagnosis or the end of the radiation, respectively, until death or end of the study period. Only 30 patientes were considered for these survival calculations. Sex and contrast enhancement exhibited statistically significant associations (P<0.05) with tumor diagnosis. These results showed a sexual predisposition of males for glial type and females for meningeal type and a greater specificity of contrast enhancement, observed on MRI, for meningioma. It was found that just the breed and the sex are prognostic factors, as they were significantly associated (P<0.05) with survival times. Boxer and labrador retriever breeds and the female sex were considered as a survival benefit in these patients. Median values were 372 days for TSPT and 446.5 days for the TST. The 1- and 2-year survival rates were, respectively, 50% and 23.3%. Thus, radiation therapy is an effective treatment option for these neoplastic cases, with better results than other therapeutic approaches.
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Dissertação de Mestrado Integrado em Medicina Veterinária
Palavras-chave
Radioterapia , Neoplasias encefálicas , Meningiomas , Glioma , Cão